A. Connective Tissue Disorders

Genetic factors and certain connective tissue disorders, such as Dupuytren's contracture, have been implicated in the pathogenesis of Peyronie's disease. An exploration of these connections sheds light on potential etiological factors.

B. Genetic Factors

Evidence suggests a hereditary component to Peyronie's disease, emphasizing the importance of family medical histories in diagnosis and risk assessment.

C. Penile Trauma or Injury

Chronic or acute trauma to the penis, whether from sexual activity, accidents, or medical procedures, is considered a potential trigger for the development of Peyronie's disease.

D. Age-Related Changes

As men age, changes in the elasticity and structure of penile tissues may contribute to the increased incidence of Peyronie's disease in older populations.