Treatment
Injection therapy
Injection therapy is a clinician-administered option for selected cases of chronic Peyronie's disease.
Injections deliver a treatment agent directly into or near the plaque. The procedure is in-clinic, not at home, and is usually delivered as a structured course rather than a single visit.
The most familiar injection, Xiaflex (collagenase), was withdrawn from the market and is no longer available. The current injection landscape is more limited and varies by region and clinician.
What to know about injection therapy
Clinician-administered, in a course
Multiple visits over weeks are typical. Self-administration is not part of standard injection therapy for Peyronie's.
Best framed for chronic, stable disease
Like surgery, injections are usually discussed once the deformity has settled. Active-phase plans are typically different.
Plaque type and location matter
Calcified or unusually positioned plaque can change the conversation about whether injections are worth pursuing.
Often paired with modelling
When injections are used, mechanical modelling between visits, gentle stretch under guidance, is part of how they are studied.
Outcomes vary and are not guaranteed
Honest framing acknowledges meaningful improvement in some men, modest in others, and limited in a third group.
Xiaflex (collagenase) was the most recognisable Peyronie's injection. It has been withdrawn from the market. Any current injection conversation will be about a different agent, regional availability, or a clinical-trial setting.
Ask whether injections are an option in your region, and whether your phase and plaque type fit the available agents.
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